Isothermal Titration Calorimeter
Product Details:
Nano Isothermal Titration Calorimetry from TA Instruments
 
Life Science professionals know that the thermodynamic driving forces of macro-molecular interactions are critical parameters for the design of effective biomedical and pharmaceutical treatments. Calorimetry has become the method of choice for characterizing the thermodynamic driving forces of critical molecular interactions and defining molecular stabilities. Calorimetric analyses are based on accurately measuring the rate of heat absorbed or evolved when the biomolecule of interest interacts specifically or non-specifically with another macromolecule or ligand (binding studies). The TA Instruments Nano ITC Standard Volume or Nano ITC Low Volume instruments are powerful tools to accurately and efficiently perform these important measurements. The Nano ITC instruments are designed to improve laboratory productivity and efficiency by performing high-sensitivity analyses on nanomolar quantities of biomolecule. This is accomplished through a combination of a high sensitivity calorimeter, accurate and stable temperature control, and efficient titrant delivery.
 
ITC Technology
 
The unique removable syringe assembly contains a mechanical paddle stirrer at the end, the speed of which is easily adjusted to accommodate the physical properties of the sample. The integrated titration assembly of the Nano ITC ensures quick-filling, simple cleaning and accurate titrations. The Nano ITC Standard Volume is available with sample cells made from 99.999 % Gold or Hastelloy C to allow for the widest range of reagent chemistry. The Nano ITC Low Volume is available with sample cell cells made from 99.999 % Gold. The true isothermal power compensation design and the choice of sample cell volumes of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analysing biological samples in-solution.
 
The Nano ITC instrument is available in two sample cell sizes. The Nano ITC Standard Volume sample cell volume is 1.0 ml. The Nano ITC Low Volume offers the lowest cell volume at 190 uL, to minimize sample consumption and at the same time provides sensitivity levels over two times better than previously achievable. Heat effects as small as 50 nanojoules are detectable in the Nano ITC Low Volume with a short term noise level of 1.4 nanowatts. Both Nano ITC instruments use cylindrical-shaped cells to make cleaning easy, solid state thermoelectric heating and cooling systems to precisely control temperature, and have the same flexible injection syringe assemblies for efficient and accurate delivery of titrant.
 
Advantages of the ITC System
 
The Nano ITC Low Volume requires substantially less sample and can reduce the time required to complete a titration by one-half. The 2X improvement in sensitivity of the Nano ITC Low Volume ensures that with 80% less sample the instrument will generate accurate and reproducible results.